• ٧٨٦
Enroll For Free
← Back to All Calculators
Pharmacology / Drug Dosing
Vancomycin AUC/MIC Dosing

Vancomycin AUC/MIC Dosing

2020 ASHP/IDSA guideline-based Bayesian approach to initial dosing

Patient Parameters
Required (20–300)
Required (100–250)
Required (18–120)
Required (0.1–15)
—
CrCl (mL/min)
—
CL (L/h)
—
Vd (L)
—
t½ (hours)
—
Total Daily Dose (mg)
400–600
AUC Target (mg·h/L)
Recommended Regimen
—
CrCl (mL/min)Suggested IntervalAUC TargetMonitoring
≥ 60Q8h400–600 mg·h/LBayesian AUC monitoring; 2 levels
30–59Q12h400–600 mg·h/LAUC monitoring; adjust per levels
< 30Q24h or less frequent400–600 mg·h/LProlonged intervals; use Bayesian PK
HD/CRRTPer protocolAUC target variesRedose per post-HD level
CrCl (C-G) = [(140−Age)×Wt]/(72×SCr) × 0.85 [female]
CL (L/h) = 0.695 × CrCl(mL/min) × 0.06 + 0.05
Vd (L) = 0.7 × ActualBodyWeight
t½ (h) = 0.693 × Vd / CL
Total Daily Dose = AUC_target × CL
2020 ASHP/IDSA Guidelines: AUC/MIC monitoring is now preferred over trough-only monitoring. Target AUC 400–600 mg·h/L assuming MIC ≤1 mg/L. Empiric starting dose typically 15–20 mg/kg Q8-12h. Obtain 2 vancomycin levels at steady state for Bayesian AUC estimation. This calculator provides initial empiric dosing estimate only.
⚕️ For qualified healthcare professionals only. Not a substitute for clinical judgment.

Select a Template for your Cv