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Nephrology / Renal
MDRD GFR Equation

MDRD GFR Equation

Modification of Diet in Renal Disease — 4-variable equation

Patient Parameters
Enter 0.1–30
Enter 18–120
— mL/min/1.73m²
StageGFRDescriptionAction
G1≥ 90Normal/HighStandard dosing; monitor
G260–89Mildly decreasedMinimal dose adjustment
G3a45–59Mild-moderate decreaseDose adjustments needed
G3b30–44Moderate-severe decreaseAvoid nephrotoxins
G415–29Severely decreasedPrepare for RRT
G5< 15Kidney failureDialysis/transplant
MDRD 4-variable:
GFR = 175 × (SCr)^(−1.154) × (Age)^(−0.203) × 0.742 [if female] × 1.212 [if African American]
Limitation: MDRD significantly underestimates GFR when true GFR >60 mL/min/1.73m². CKD-EPI 2021 is preferred for all patients. MDRD reports GFR as ">60" when calculated above that threshold. Race-based multiplier (African American) is included for historical reference but race-free CKD-EPI 2021 is now recommended.
⚕️ For qualified healthcare professionals only. Not a substitute for clinical judgment.

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