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Pharmacology / Drug Dosing
Lithium Dosing Calculator

Lithium Dosing Calculator

Empiric starting dose with renal-adjusted clearance estimation

Patient Parameters
Required (18–100)
Required (30–300)
Required
Required (0.4–1.5)
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CrCl (mL/min)
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Li Clearance (mL/min)
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t½ (hours)
Recommended Starting Dose
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Lithium Level (mEq/L)Clinical StatusSigns / Action
0.6–0.8Maintenance therapeuticStandard maintenance range
0.8–1.2Acute mania therapeuticStandard acute treatment range
1.2–1.5High-normalMonitor closely; fine tremor, GI upset
1.5–2.0Early toxicityCoarse tremor, ataxia, confusion — reduce dose
> 2.0Severe toxicitySeizures, arrhythmia — hold Li; supportive care; HD if severe
Drug Interactions: Increase Li levels: NSAIDs (indomethacin, ibuprofen), thiazide diuretics, ACE inhibitors, ARBs, low-sodium diet. Decrease Li levels: caffeine, theophylline, acetazolamide. Monitor levels weekly initially, then every 3–6 months. Draw level 12 hours after last dose (trough). Ensure adequate hydration and sodium intake. Monitor renal function and thyroid q6–12 months.
For qualified healthcare professionals only. Not a substitute for clinical judgment.

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