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Endocrinology & Metabolism
HOMA-IR
Endocrinology
HOMA-IR — Insulin Resistance Calculator
Homeostatic Model Assessment of Insulin Resistance
Please enter a valid fasting insulin value.
Please enter a valid fasting glucose value.
✓ HOMA-IR Results
Clinical Note: HOMA-IR thresholds vary by population. Values >2.5–3.0 are commonly used as the clinical cut-off for insulin resistance. Interpretation should be combined with clinical context.
Reference Table
HOMA-IRInterpretationClinical Action
<1.0Optimal sensitivityMaintain lifestyle
1.0–1.9NormalMonitor
2.0–2.9Early resistanceLifestyle modification
3.0–4.9Insulin resistanceConsider metformin, lifestyle Rx
≥5.0Significant resistanceComprehensive metabolic evaluation
Formulas
HOMA-IR = (Fasting Glucose [mmol/L] × Fasting Insulin [µIU/mL]) / 22.5
HOMA-β = (20 × Insulin [µIU/mL]) / (Glucose [mmol/L] − 3.5)
Glucose conversion: mg/dL × 0.0555 = mmol/L
Insulin conversion: pmol/L ÷ 6.945 = µIU/mL

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