Weight-based unfractionated heparin dosing with aPTT adjustment
| aPTT (sec) | Rebolus | Rate Change | Hold |
|---|---|---|---|
| < 35 | 80 U/kg | Increase by 4 U/kg/hr | None |
| 35–49 | 40 U/kg | Increase by 2 U/kg/hr | None |
| 50–70 | None | No change (therapeutic) | None |
| 71–90 | None | Decrease by 1 U/kg/hr | None |
| 91–120 | None | Decrease by 2 U/kg/hr | 30 min |
| > 120 | None | Decrease by 3 U/kg/hr | 60 min |
