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Nephrology / Renal
Creatinine Clearance (Cockcroft-Gault)

Creatinine Clearance — Cockcroft-Gault

Standard equation for drug dosing renal adjustments

Patient Parameters
Enter age 18–120
Enter weight 20–300 kg
Enter height 100–250 cm
Enter valid creatinine
—
CrCl (Actual Wt) mL/min
—
CrCl (IBW) mL/min
—
IBW (kg)
Drug Dosing Categories (CrCl-based)
CrCl RangeCategoryDrug Dosing ActionExamples
≥ 50 mL/minNormalStandard dosesMost drugs: full dose
30–49 mL/minMild impairmentDose reduction often neededApixaban, metformin caution
15–29 mL/minModerate impairmentSignificant dose reductionAvoid metformin, NOAC adjustments
< 15 mL/minSevere / ESRDMany drugs contraindicatedDialysis dosing required
Cockcroft-Gault:
CrCl = [(140 − Age) × Weight(kg)] / (72 × SCr) × 0.85 [if female]
IBW male = 50 + 2.3 × (Height_inches − 60)
IBW female = 45.5 + 2.3 × (Height_inches − 60)
ABW = IBW + 0.4 × (ActualWt − IBW) [use if obese]
Clinical Notes: Use actual body weight unless patient is obese (BMI >30), then use adjusted body weight (ABW). If actual weight < IBW, use actual weight. Cockcroft-Gault (not eGFR) is used for most drug dosing decisions per FDA and pharmacokinetic studies.
⚕️ For qualified healthcare professionals only. Not a substitute for clinical judgment.

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