Estimate toxic alcohol blood levels from osmol gap and determine treatment thresholds
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Osmol Gap (Direct Entry)
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Results
Substance—
Calculated Osmolality—
Osmol Gap Used—
Estimated Blood Level—
Toxicity Severity—
Hemodialysis Indication—
Treatment Guidance
Calculation Details
Osmol Gap Multiplier Reference Table
Substance
Multiplier (mg/dL per mOsm/kg)
MW (g/mol)
Toxic Threshold
Ethanol
4.6
46
>80 mg/dL (legal); >300 mg/dL severe
Methanol
3.2
32
>20 mg/dL toxic; >50 mg/dL HD indicated
Ethylene Glycol
6.2
62
>20 mg/dL toxic; >50 mg/dL HD indicated
Isopropanol
6.0
60
>50 mg/dL significant; >400 mg/dL severe
Medical Disclaimer: This calculator is intended for educational and clinical decision-support purposes only. Results must be interpreted by a qualified healthcare professional in the context of the full clinical picture. Always consult Poison Control (1-800-222-1222 in the US) and institutional protocols for management of toxic ingestions. Do not use as a substitute for clinical judgment.
