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Vancomycin AUC/MIC Dosing
2020 ASHP/IDSA guideline-based Bayesian approach to initial dosing
Patient Parameters
Required (20–300)
Required (100–250)
Required (18–120)
Required (0.1–15)
—
CrCl (mL/min)
—
CL (L/h)
—
Vd (L)
—
t½ (hours)
—
Total Daily Dose (mg)
400–600
AUC Target (mg·h/L)
Recommended Regimen
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| CrCl (mL/min) | Suggested Interval | AUC Target | Monitoring |
|---|---|---|---|
| ≥ 60 | Q8h | 400–600 mg·h/L | Bayesian AUC monitoring; 2 levels |
| 30–59 | Q12h | 400–600 mg·h/L | AUC monitoring; adjust per levels |
| < 30 | Q24h or less frequent | 400–600 mg·h/L | Prolonged intervals; use Bayesian PK |
| HD/CRRT | Per protocol | AUC target varies | Redose per post-HD level |
CrCl (C-G) = [(140−Age)×Wt]/(72×SCr) × 0.85 [female]
CL (L/h) = 0.695 × CrCl(mL/min) × 0.06 + 0.05
Vd (L) = 0.7 × ActualBodyWeight
t½ (h) = 0.693 × Vd / CL
Total Daily Dose = AUC_target × CL
CL (L/h) = 0.695 × CrCl(mL/min) × 0.06 + 0.05
Vd (L) = 0.7 × ActualBodyWeight
t½ (h) = 0.693 × Vd / CL
Total Daily Dose = AUC_target × CL
2020 ASHP/IDSA Guidelines: AUC/MIC monitoring is now preferred over trough-only monitoring. Target AUC 400–600 mg·h/L assuming MIC ≤1 mg/L. Empiric starting dose typically 15–20 mg/kg Q8-12h. Obtain 2 vancomycin levels at steady state for Bayesian AUC estimation. This calculator provides initial empiric dosing estimate only.
