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SOFA Score — Sequential Organ Failure Assessment
Six-organ ICU mortality predictor; central to Sepsis-3 definition
Respiration
Coagulation
Liver
Cardiovascular
CNS
Renal
—
SOFA Score / 24
—
Resp
—
Coag
—
Liver
—
Cardio
—
CNS
—
Renal
Predicted Mortality:
Sepsis-3 Criteria: Suspected infection + SOFA increase ≥2 from baseline = Sepsis. SOFA ≥2 with vasopressors + lactate >2 despite fluids = Septic Shock.
SOFA Mortality Reference
| SOFA Score | Predicted Mortality |
|---|---|
| 0–6 | <10% |
| 7–9 | 15–20% |
| 10–12 | 40–50% |
| >11 | >50% |
| >14 | >90% |
SOFA = Respiration + Coagulation + Liver + Cardiovascular + CNS + Renal (0–24)
Sepsis-3: Suspected infection + SOFA ≥2 point increase from baseline
Vasopressor doses in µg/kg/min (dopamine) or µg/kg/min (epinephrine, norepinephrine)
Sepsis-3: Suspected infection + SOFA ≥2 point increase from baseline
Vasopressor doses in µg/kg/min (dopamine) or µg/kg/min (epinephrine, norepinephrine)
Sepsis-3: SOFA replaced SIRS criteria. Serial SOFA scores track clinical trajectory — improving scores suggest treatment response. Baseline SOFA assumed to be 0 in patients without pre-existing organ dysfunction.
For clinical decision support only. Not a substitute for professional medical judgment.
