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Renal Drug Dose Adjustment Reference
Enter CrCl to highlight appropriate doses for renally-cleared drugs
Enter Creatinine Clearance
Enter CrCl 1–200
Antibiotics
| Drug | Normal Dose | CrCl ≥50 | CrCl 30–49 | CrCl 15–29 | CrCl <15 / HD |
|---|---|---|---|---|---|
| Amoxicillin | 500mg Q8h | Standard | Standard | Q12h | Q24h |
| Pip-Tazo | 4.5g Q6h | Standard | 4.5g Q8h | 2.25g Q6h | 2.25g Q8h |
| Ciprofloxacin IV | 400mg Q12h | Standard | Standard | 200mg Q12h | 200mg Q12h |
| TMP-SMX (DS) | 1 DS Q12h | Standard | 50% dose | Avoid | Avoid |
| Acyclovir IV | 10mg/kg Q8h | Standard | Q12h | Q24h | 5mg/kg Q24h |
Cardiovascular / Diabetes
| Drug | Normal Dose | CrCl ≥50 | CrCl 30–49 | CrCl 15–29 | CrCl <15 / HD |
|---|---|---|---|---|---|
| Metformin | 500–2000mg/day | Standard | Use caution | Avoid | Avoid |
| Digoxin | 0.125–0.25mg QD | Standard | 0.125mg QD | 0.0625–0.125mg QD | 0.0625mg Q48h |
| Allopurinol | 300mg QD | Standard | 200mg QD | 100mg QD | 50–100mg QD |
| Colchicine | Standard | Standard | Reduce 50% | Reduce 50% | Avoid |
Neurology / Analgesics
| Drug | Normal Dose | CrCl ≥50 | CrCl 30–49 | CrCl 15–29 | CrCl <15 / HD |
|---|---|---|---|---|---|
| Gabapentin | 300–1200mg TID | Standard | 300–600mg BID | 300mg QD | 100–300mg QD |
Note: This table is a general reference. Always verify with current prescribing information, institutional protocols, and clinical pharmacist. CrCl from Cockcroft-Gault is used for drug dosing (not eGFR). HD = hemodialysis. Highlighted column = recommended dose for entered CrCl.
