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HOMA-β = (20 × Insulin [µIU/mL]) / (Glucose [mmol/L] − 3.5)
Glucose conversion: mg/dL × 0.0555 = mmol/L
Insulin conversion: pmol/L ÷ 6.945 = µIU/mL
Endocrinology
HOMA-IR — Insulin Resistance Calculator
Homeostatic Model Assessment of Insulin Resistance
Please enter a valid fasting insulin value.
Please enter a valid fasting glucose value.
✓ HOMA-IR Results
Clinical Note: HOMA-IR thresholds vary by population. Values >2.5–3.0 are commonly used as the clinical cut-off for insulin resistance. Interpretation should be combined with clinical context.
Reference Table
| HOMA-IR | Interpretation | Clinical Action |
|---|---|---|
| <1.0 | Optimal sensitivity | Maintain lifestyle |
| 1.0–1.9 | Normal | Monitor |
| 2.0–2.9 | Early resistance | Lifestyle modification |
| 3.0–4.9 | Insulin resistance | Consider metformin, lifestyle Rx |
| ≥5.0 | Significant resistance | Comprehensive metabolic evaluation |
Formulas
HOMA-IR = (Fasting Glucose [mmol/L] × Fasting Insulin [µIU/mL]) / 22.5HOMA-β = (20 × Insulin [µIU/mL]) / (Glucose [mmol/L] − 3.5)
Glucose conversion: mg/dL × 0.0555 = mmol/L
Insulin conversion: pmol/L ÷ 6.945 = µIU/mL
