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Shortcode 106 — Laboratory
Creatinine Clearance / eGFR Calculator
Calculates CrCl via Cockcroft-Gault with body weight adjustment, CKD-EPI 2021 (race-free), and MDRD 4-variable eGFR. Includes CKD staging and drug dosing thresholds.
Patient Parameters
Must be ≥18 years
Enter a valid age (18–120)
Used for IBW and CKD-EPI coefficients
kg
Enter a valid weight (20–300 kg)
cm
Enter a valid height (100–230 cm)
mg/dL — normal: M 0.74–1.35, F 0.59–1.04
Enter a valid creatinine (0.1–20 mg/dL)
eGFR Results
Cockcroft-Gault
—
mL/min
—
CKD-EPI 2021
—
mL/min/1.73m²
—
MDRD 4-Variable
—
mL/min/1.73m²
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CKD Stage (based on CKD-EPI 2021)
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—
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CKD Staging Reference
| Stage | eGFR (mL/min/1.73m²) | Description |
|---|---|---|
| G1 | ≥90 | Normal or High |
| G2 | 60–89 | Mildly decreased |
| G3a | 45–59 | Mildly to moderately decreased |
| G3b | 30–44 | Moderately to severely decreased |
| G4 | 15–29 | Severely decreased |
| G5 | <15 | Kidney failure |
Drug Dosing Thresholds
| eGFR Range | Clinical Guidance | Key Drug Considerations |
|---|---|---|
| >60 mL/min | Normal dosing for most drugs | Minimal renal dose adjustments required for most common medications |
| 45–60 mL/min | Caution for some drugs | Metformin: use with caution; some antibiotics require monitoring |
| 30–44 mL/min | Reduce doses | Metformin: use with caution (consider stopping); DOACs dose-reduce; many antibiotics require adjustment |
| 15–30 mL/min | Significant reductions needed | Metformin: STOP; many drugs contraindicated; DOAC adjustments critical; NSAIDs avoid |
| <15 / Dialysis | Major restrictions; nephrology consult | Most renally-cleared drugs require specialist guidance; dialysis-specific dosing applies |
Formulas Used
Cockcroft-Gault: IBW (Male) = 50 + 2.3 x ((Height_cm / 2.54) - 60) IBW (Female) = 45.5 + 2.3 x ((Height_cm / 2.54) - 60) If ABW > 1.3 x IBW => use Adjusted BW = IBW + 0.4 x (ABW - IBW) Else if ABW < IBW => use ABW Else use ABW (within normal range) CrCl = [(140 - Age) x Weight / (72 x SCr)] x (0.85 if female) CKD-EPI 2021 (race-free): kappa = 0.7 (female) / 0.9 (male) alpha = -0.241 (female) / -0.302 (male) eGFR = 142 x min(SCr/k,1)^alpha x max(SCr/k,1)^(-1.200) x 0.9938^Age x (x1.012 if female) MDRD 4-Variable: eGFR = 175 x SCr^(-1.154) x Age^(-0.203) x (x0.742 if female)
Medical Disclaimer
CKD-EPI 2021 is the recommended race-free equation (KDIGO 2024). Cockcroft-Gault is used primarily for drug dosing. MDRD is provided for historical reference and may be less accurate at higher GFR values. Results should be interpreted in clinical context. This calculator does not replace clinical judgment or laboratory reporting.
