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Corrected Sodium (Hyperglycemia)
Hematology / Electrolytes
Hyperglycemia causes osmotic water shift into the extracellular space, diluting serum sodium. Corrected sodium reflects the true sodium concentration after glucose normalization. Two formulas are available: Katz (1973) and Hillier (1999), with Hillier preferred for glucose >400 mg/dL.
Formula
Katz: Corrected Na = Measured Na + 1.6 × [(Glucose − 100) / 100]
Hillier: Corrected Na = Measured Na + 2.4 × [(Glucose − 100) / 100]
For Glucose >400 mg/dL: Hillier formula preferred
Hillier: Corrected Na = Measured Na + 2.4 × [(Glucose − 100) / 100]
For Glucose >400 mg/dL: Hillier formula preferred
Reference
| Condition | Sodium | Notes |
|---|---|---|
| Hyponatremia | <136 mEq/L | Evaluate cause |
| Normal | 136–145 mEq/L | — |
| Hypernatremia | >145 mEq/L | Free water deficit |
Clinical Notes
In DKA and HHS, sodium is diluted by osmotic water shift from hyperglycemia. Corrected sodium reflects the true sodium concentration that would exist after glucose normalization. A rising corrected sodium in DKA indicates appropriate osmotic response; persistently low corrected Na may indicate a separate hyponatremia etiology. Management of DKA/HHS targets fluid resuscitation and insulin therapy to normalize glucose and sodium together.
For educational use only. Clinical decisions must incorporate full patient evaluation.
