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Creatinine Clearance — Cockcroft-Gault
Standard equation for drug dosing renal adjustments
Patient Parameters
Enter age 18–120
Enter weight 20–300 kg
Enter height 100–250 cm
Enter valid creatinine
—
CrCl (Actual Wt) mL/min
—
CrCl (IBW) mL/min
—
IBW (kg)
Drug Dosing Categories (CrCl-based)
| CrCl Range | Category | Drug Dosing Action | Examples |
|---|---|---|---|
| ≥ 50 mL/min | Normal | Standard doses | Most drugs: full dose |
| 30–49 mL/min | Mild impairment | Dose reduction often needed | Apixaban, metformin caution |
| 15–29 mL/min | Moderate impairment | Significant dose reduction | Avoid metformin, NOAC adjustments |
| < 15 mL/min | Severe / ESRD | Many drugs contraindicated | Dialysis dosing required |
Cockcroft-Gault:
CrCl = [(140 − Age) × Weight(kg)] / (72 × SCr) × 0.85 [if female]
IBW male = 50 + 2.3 × (Height_inches − 60)
IBW female = 45.5 + 2.3 × (Height_inches − 60)
ABW = IBW + 0.4 × (ActualWt − IBW) [use if obese]
CrCl = [(140 − Age) × Weight(kg)] / (72 × SCr) × 0.85 [if female]
IBW male = 50 + 2.3 × (Height_inches − 60)
IBW female = 45.5 + 2.3 × (Height_inches − 60)
ABW = IBW + 0.4 × (ActualWt − IBW) [use if obese]
Clinical Notes: Use actual body weight unless patient is obese (BMI >30), then use adjusted body weight (ABW). If actual weight < IBW, use actual weight. Cockcroft-Gault (not eGFR) is used for most drug dosing decisions per FDA and pharmacokinetic studies.
