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Alcohols / Ethylene Glycol Blood Level Estimation
Estimate toxic alcohol blood levels from osmol gap and determine treatment thresholds
Substance Selection
Osmol Gap (Direct Entry)
Leave blank to calculate from serum values below
Auto-Calculate Osmol Gap (Optional)
Please enter either the Osmol Gap directly, or all four serum values (Osmolality, Na, BUN, Glucose).
Results
Substance
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Osmol Gap Used
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Estimated Blood Level
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Toxicity Severity
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Hemodialysis Indication
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Osmol Gap Multiplier Reference Table
| Substance | Multiplier (mg/dL per mOsm/kg) | MW (g/mol) | Toxic Threshold |
|---|---|---|---|
| Ethanol | 4.6 | 46 | >80 mg/dL (legal); >300 mg/dL severe |
| Methanol | 3.2 | 32 | >20 mg/dL toxic; >50 mg/dL HD indicated |
| Ethylene Glycol | 6.2 | 62 | >20 mg/dL toxic; >50 mg/dL HD indicated |
| Isopropanol | 6.0 | 60 | >50 mg/dL significant; >400 mg/dL severe |
Medical Disclaimer: This calculator is intended for educational and clinical decision-support purposes only. Results must be interpreted by a qualified healthcare professional in the context of the full clinical picture. Always consult Poison Control (1-800-222-1222 in the US) and institutional protocols for management of toxic ingestions. Do not use as a substitute for clinical judgment.
